Tetrahedron

Tricyclic isoindolines by Heck cyclization

G Satyanarayana, ME Maier

Index: Satyanarayana, Gedu; Maier, Martin E. Tetrahedron, 2012 , vol. 68, # 6 p. 1745 - 1749

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Citation Number: 13

Abstract

A series of 4-formyl esters 8a–d was prepared by Michael addition of an enamine with ethyl acrylate. A subsequent condensation with 2-bromobenzylamines 3 gave rise to cyclic enamides 9aa–dd. In a Heck cyclization reaction tricyclic isoindoles 10aa–dd were formed in good yields.

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