A Facile Pathway to Enantiomerically Enriched 3??Hydroxy??2??Oxindoles: Asymmetric Intramolecular Arylation of α??Keto Amides Catalyzed by a Palladium–DifluorPhos …

L Yin, M Kanai, M Shibasaki

Index: Yin, Liang; Kanai, Motomu; Shibasaki, Masakatsu Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7620 - 7623

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Citation Number: 55

Abstract

Organic group-transfer reactions from halides and triflates to carbonyl compounds are a useful CÀC bond-forming transformation. An example is the chromium-mediated Nozaki– Hiyama–Kishi (NHK) reaction,[1] whose utility has been demonstrated by numerous applications to total syntheses of complex natural products and biologically active compounds.[2] The requirement for stoichiometric amounts of toxic chromium salts—a ...

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