Discovery of FR115092: A novel antinephritic agent

…, N Igari, N Seki, Y Sudo, T Manda, F Nishigaki…

Index: Ogino, Takashi; Tsuji, Kiyoshi; Tojo, Takashi; Igari, Norihiro; Seki, Nobuo; Sudo, Yu; Manda, Toshitaka; Nishigaki, Fusako; Matsuo, Masaaki Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 1 p. 75 - 80

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Citation Number: 13

Abstract

A series of dapsone-related 4-aminophenyl and 2-aminothiazolyl derivatives was prepared, and their antinephritic activity and blood toxicity were evaluated. 5-(2-Pyridylsulfonyl)-2- thiazolamine (FR115092, 26) was effective against two nephritis models, namely graft- versus-host disease (GVHD) and autoimmune W/BF1 mice, and showed none of the blood toxicity observed with dapsone.