Synthesis of substituted heterocycles. Simple method for the introduction of the N-hydroxyurea functionality
YY Ku, RR Patel, BA Roden, DP Sawick
Index: Ku, Yi-Yin; Patel, Ramesh R.; Roden, Brian A.; Sawick, David P. Tetrahedron Letters, 1994 , vol. 35, # 33 p. 6017 - 6020
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Citation Number: 18
Abstract
Abstract A simple method for the introduction of the N-hydroxyurea functionality has been developed. This involves conjugate addition of hydroxylamine to a vinylsulfone substrate. This method was successfully used in a facile synthesis of the 5-lipoxygenase inhibitors, zileuton and A-69412.
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