Synthesis and biological properties of novel phosphotriesters: A new approach to the introduction of biologically active nucleotides into cells

…, RT Walker, J Balzarini, E De Clercq

Index: Farrow, Stuart N.; Jones, A. Stanley; Kumar, Ajit; Walker, Richard T.; Balzarini, Jan; Clercq, Erik de Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1400 - 1406

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Citation Number: 74

Abstract

A series of aryl bis (3'-0-acetylthymidin-5'-yl) phosphate derivatives have been synthesized in order to find a suitable aryl derivative which would hydrolyze to the bis (nucleosid-5'-yl) phosphate under physiological conditions. The 4-(methylsulfony1) phenyl derivative was selected and 4-(methylsulfony1) phenyl bis [(E)-5-(2-bromovinyl)-2'-deoxyuridin-5'-yl] phosphate (6d) and bis [2-(guanin-9-ylmethoxy) ethoxy]-4-(methylsulfonyl) phenyl ...