Structure-based, C2 symmetric inhibitors of HIV protease

…, WE Kohlbrenner, NE Wideburg, DA Paul…

Index: Kempf; Norbeck; Codacovi; Wang; Kohlbrenner; Wideburg; Paul; Knigge; Vasavanonda; Craig-Kennard; et al. Journal of medicinal chemistry, 1990 , vol. 33, # 10 p. 2687 - 2689

Full Text: HTML

Citation Number: 207

Abstract

New Zealand rabbits (2.2-2.3 kg) were fed a cholesterol-rich die P for 10 days to induce increases in arterial ACAT activity'” and then switched to Purina chow lb (calculated to provide 50 mg kg-'day-'). After 6 days, the aortas were excised, incubated in vitro with [l-14C] oleate for 3 h, and ACAT activity was evaluated by the formation of cholesteryl [“CJ-oleate. 16 Liver minces” from male Sprague-Dawley rats (435-460 g) that received a Purina chow ...

Related Articles:

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

[Kempf, Dale J.; Sowin, Thomas J.; Doherty, Elizabeth M.; Hannick, Steven M.; Codavoci, LynnMarie; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5692 - 5700]

Stereocontrolled synthesis of C2-symmetric and pseudo-C2-symmetric diamino alcohols and diols for use in HIV protease inhibitors

[Kempf, Dale J.; Sowin, Thomas J.; Doherty, Elizabeth M.; Hannick, Steven M.; Codavoci, LynnMarie; et al. Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5692 - 5700]

Stereocontrolled synthesis of pseudo C 2-symmetric 1, 3-diamino-2-propanol core units of HIV protease inhibitors

[Dondoni, Alessandro; Perrone, Daniela Tetrahedron Letters, 1997 , vol. 38, # 3 p. 499 - 502]

Stereocontrolled synthesis of pseudo C 2-symmetric 1, 3-diamino-2-propanol core units of HIV protease inhibitors

[Dondoni, Alessandro; Perrone, Daniela Tetrahedron Letters, 1997 , vol. 38, # 3 p. 499 - 502]

More Articles...