Discovery of a novel lead structure for anti-malarials

…, P Wißner, HM Dahse, H Jomaa, M Schlitzer

Index: Wiesner, Jochen; Wissner, Pia; Dahse, Hans-Martin; Jomaa, Hassan; Schlitzer, Martin Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 785 - 792

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Citation Number: 27

Abstract

From a library of 61 compounds available from former studies 2, 5-bis- acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti- malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials.

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