Synthesis of 5-isoxazol-5-yl-2′-deoxyuridines exhibiting antiviral activity against HSV and several RNA viruses

YS Lee, SM Park, BH Kim

Index: Lee, Yoon-Suk; Park, Sun Min; Kim, Byeang Hyean Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 4 p. 1126 - 1128

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Citation Number: 75

Abstract

This paper describes a simple method for synthesizing a small library of 5-isoxazol-5-yl-2′- deoxyuridines from 5-iodo-2′-deoxyuridine. Nitrile oxides were generated in situ from oximes using a commercial bleaching agent; their cycloaddition with 5-ethynyl-2′- deoxyuridine yielded isoxazoles possessing activity against herpes simplex viruses 1 and 2, Encephalomyocarditis virus, Coxsackie B3, and vesicular stomatitis virus; these ...