Clean three-step synthesis of 4, 5-dihydro-1 H-pyrazoles starting from alcohols using polymer supported reagents

MH Bolli, SV Ley

Index: Haunert, Frank; Bolli, Martin H.; Hinzen, Berthold; Ley, Steven V. Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 15 p. 2235 - 2237

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Citation Number: 49

Abstract

Nafion-TMS mediated Mukaiyama aldol reaction of silyl enol ethers with aldehydes, obtained from mild oxidation of alcohols with polymer supported perruthenate (PSP), yielded α, β-unsaturated ketones, which upon treatment with hydrazines allowed the clean synthesis of 4, 5-dihydro-1H-pyrazoles.