Tetrahedron Letters

BOTPPI, a new Wittig salt for the synthesis of 12-(S)-hydroxy-eicosatetraenoic acid [12-(S)-HETE]

MA Christiansen, MB Andrus

Index: Christiansen, Michael A.; Andrus, Merritt B. Tetrahedron Letters, 2012 , vol. 53, # 36 p. 4805 - 4808

Full Text: HTML

Citation Number: 1

Abstract

An efficient route to (Z)-(8-benzyloxy-8-oxooct-3-en-1-yl) triphenylphosphonium iodide, or BOTPPI, is disclosed, complete with full experimental details, NMR spectra, and HRMS data. BOTPPI serves as a surrogate for (Z)-(8-methoxy-8-oxooct-3-en-1-yl) triphenylphosphonium iodide, or MOTPPI, a Wittig salt previously used in two 12-HETE syntheses. BOTPPI has the advantage over MOTPPI of being derived from a sequence for which every intermediate is ...

Related Articles:

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

[Weber; Halgren; Doyle; Lynch; Siegl; Parsons; Greenlee; Patchett Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2692 - 2701]

Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors

[Weber; Halgren; Doyle; Lynch; Siegl; Parsons; Greenlee; Patchett Journal of Medicinal Chemistry, 1991 , vol. 34, # 9 p. 2692 - 2701]

Oxone®: A Convenient Reagent for the Oxidation of Acetals

[Curini, Massimo; Epifano, Francesco; Marcotullio, Maria Carla; Rosati, Ornelio Synlett, 1999 , # 6 p. 777 - 779]

Synthesis of Protein Conjugates of 2-Carboxy-L-Arabinitol 5-Phosphate and 2-Carboxy-L-Ribitol 5-Phosphate

[Gourlaouen, Nelly; Florentin, Dominique; Marquet, Andree Journal of Carbohydrate Chemistry, 1998 , vol. 17, # 8 p. 1219 - 1238]

More Articles...