Anthracene-9, 10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2, 6-disubstituted derivatives

M Agbandje, TC Jenkins, R McKenna…

Index: Agbandje, Mavis; Jenkins, Terence C.; McKenna, Robert; Reszka, Anthony P.; Neidle, Stephen Journal of Medicinal Chemistry, 1992 , vol. 35, # 8 p. 1418 - 1429

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Citation Number: 90

Abstract

(NHCO (CH2) nNR2) 2, where Ar= anthracene-9, lO-dione and n= 1 or 2, have been synthesized by treatment of the corresponding bis (w-haloalkanarm'do) derivatives with appropriate secondary amines. The DNA-binding properties of theae compounds were ...