Tetrahedron letters

For-Met-Δ z Leu-Phe-OMe: A new active analog of chemotactic N-formyltripeptides with β-turn crystal conformation

GP Zecchini, MP Paradisi, I Torrini, G Lucente…

Index: Zecchini, Giampiero Pagani; Paradisi, Mario Paglialunga; Torrini, Ines; Lucente, Gino; Gavuzzo, Enrico; et al. Tetrahedron Letters, 1991 , vol. 32, # 34 p. 4375 - 4376

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Citation Number: 13

Abstract

Abstract The title Δ z Leu containing N-formyltripeptide 2, has been synthesized and found active in the superoxide production whereas inactive in the stimulation of human neutrophil migration. The X-ray crystallographic analysis reveals that 2 adopts a β-turn conformation stabilized by an intramolecular H-bond.