Mechanism for the solvolytic decomposition of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine in aqueous solutions

…, MF Tschantz, JS Vaughn, DN Wichems…

Index: Galtress; Morrow; Nag; Smalley; Tschantz; Vaughn; Wichems; Ziglar; Fishbein Journal of the American Chemical Society, 1992 , vol. 114, # 4 p. 1406 - 1411

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Citation Number: 25

Abstract

Abstract: A study of the kinetics and products of the decomposition of the carcinogen N- methyl-N'-nitro-N-nitrosoguanidine (MNNG) in aqueous buffered solutions, 1 M ionic strength at 40 OC, has been carried out over the range pH 4-10. The pKa of MNNG has been determined to be 7.73 f 0.03. Rate constants kht for the buffer-independent, solvolytic, decomposition reaction increase with increasing pH above pH 6. The slope of the plot of ...