Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones
…, Y Nakanishi, P Nampoothiri, T Hackl, E Hamel…
Index: Xia, Yi; Yang, Zheng-Yu; Hour, Mann-Jen; Kuo, Sheng-Chu; Xia, Peng; Bastow, Kenneth F; Nakanishi, Yuka; Nampoothiri, Priya; Hackl, Torben; Hamel, Ernest; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 9 p. 1193 - 1196
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Citation Number: 153
Abstract
A series of 2′, 3′, 4′, 6, 7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8–10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx.
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