Metabolism of 1, 2-dichloro-1-fluoroethane and 1-fluoro-1, 2, 2-trichloroethane: electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation

H Yin, MW Anders, JP Jones

Index: Yin, Hequn; Anders; Jones, Jeffrey P. Chemical Research in Toxicology, 1996 , vol. 9, # 1 p. 50 - 57

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Citation Number: 18

Abstract

1, 2-Dichloro-1-fluoroethane (HCFC-141) and 1, 1, 2-trichloro-2-fluoroethane (HCFC-131) were chosen as models to study the regioselectivity of halogenated alkane metabolism. Metabolites in the urine of rats given HCFC-131 ip were the following: inorganic fluoride, chlorofluoroacetic acid, dichloroacetic acid, N-(2-hydroxyethyl) chlorofluoroacetamide, and three unidentified minor metabolites. In vitro incubation of HCFC-131 with either rat liver ...