Diethyl??and Di??n??Butyltin (IV) 3??Amino??4??Methylbenzoates: Synthesis, Spectroscopic Characterization and in Vitro Antitumor Activity

…, AE Khloufi, M Biesemans, B Mahieu…

Index: Gielen, Marcel; Khloufi, Abdelaziz El; Biesemans, Monique; Mahieu, Bernard; Willem, Rudolph Bulletin des Societes Chimiques Belges, 1992 , vol. 101, # 3 p. 243 - 248

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Abstract

Abstract Diethyl-and di-n-butyltin (IV) oxides react with 3-amino-4-methylbenzoic acid in a 1: 2 (a) and 1: 1 (b) molar ratio to yield dialkyltin compounds of the types R 2 Sn [O 2 CC 6 H 3- 3-NH 2-4-CH 3] 2 (a) and {[R 2 Sn (O 2 CC 6 H 3-3-NH 2-4-CH 3)] 2 O} 2 (b). The compounds obtained were characterized by 1 H, 13 C, 119 Sn NMR and by Mössbauer spectroscopy. Compound 1a was tested in vitro against two human tumor cell lines, MCF- ...