Synthesis and evaluation of DPPH and anti-inflammatory activities of 2, 6-bisbenzylidenecyclohexanone and pyrazoline derivatives

…, CL Tham, CY Liew, A Syahida, MBA Rahman…

Index: Lam, Kok Wai; Tham, Chau Ling; Liew, Choi Yi; Syahida, Ahmad; Rahman, Mohd. Basyaruddin Abdul; Israf, Daud A.; Lajis, Nordin H. Medicinal Chemistry Research, 2012 , vol. 21, # 3 p. 333 - 344

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Citation Number: 8

Abstract

Abstract A series of thirty three 2, 6-bisbenzylidenecyclohexanone and pyrazoline derivatives were synthesized and evaluated for inhibitory activities on IFN-γ/LPS-activated RAW 264.7 cells and DPPH radical scavenging activity. Compounds 8, 9, and 11a demonstrated significant NO inhibitory activity as compared to L-NAME and curcumin with IC 50 values of 6.68±0.16, 6.09±0.46, and 6.84±0.12 μM, respectively. Apparently the ...