Efficient Preparation of a Key Intermediate in the Synthesis of Roxifiban by Enzymatic Dynamic Kinetic Resolution on Large Scale¶

…, P Ma, E Gorko, PN Confalone, J Fortunak…

Index: Pesti, Jaan A.; Yin, Jinguao; Zhang, Lin-Hua; Anzalone, Luigi; Waltermire, Robert E.; Ma, Philip; Gorko, Edward; Confalone, Pat N.; Fortunak, Joseph; Silverman, Charlotte; Blackwell, John; Chung; Hrytsak, Michael D.; Cooke, Mary; Powell, Lakisha; Ray, Charles Organic Process Research and Development, 2004 , vol. 8, # 1 p. 22 - 27

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Citation Number: 23

Abstract

Additional information is presented for the transformation of a kinetic resolution into a dynamic kinetic resolution of the isobutyl ester 5b to form the acid 2 in high yield and ee via the intermediacy of a thioester 6c,(Pesti, JA; Yin, J.; Zhang, L.-H; Anzalone, LJ Am. Chem. Soc. 2001, 123, 11075-11076.). The development of optimized reaction conditions for the preparation of 6c, its dynamic kinetic resolution to 2, and the scale-up of both reactions ...