Tetrahedron Letters

Enantioselective synthesis of β-hydroxyisobutyric acid: a useful synthon in the synthesis of polypropionate-type natural products

W Choy, P Ma, S Masamune

Index: Choy, William; Ma, Philip; Masamune, Satoru Tetrahedron Letters, 1981 , vol. 22, # 37 p. 3555 - 3556

Full Text: HTML

Citation Number: 18

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The aldol reaction of formaldehyde with the dicyclopentylborinyl enolate derived from -(or -) 1-tert-butyldimethylsilyloxy-l-cyclohexylbutan-2-one, followed by desilylation and sodium meta-periodate oxidation, provides -(or -) β-hydroxyisobutyric acid.

Related Articles:

Asymmetric synthesis of chiral Roche ester and its derivatives via Rh-catalyzed enantioselective hydrogenation with chiral phosphine-phosphoramidite ligands

[Tetrahedron Asymmetry, , vol. 20, # 2 p. 210 - 213]

Synthesis of Chiral 2??Hydroxy??1??methylpropanoates by Rhodium??Catalyzed Stereoselective Hydrogenation of α??(Hydroxymethyl)??acrylate Derivatives

[Advanced Synthesis and Catalysis, , vol. 350, # 16 p. 2533 - 2543]

Enantiotopically selective oxidation of. alpha.,. omega.-diols with enzyme systems of microorganisms

[Journal of Organic Chemistry, , vol. 47, # 12 p. 2400 - 2404]

More Articles...