Enzyme-catalyzed aldol condensation for asymmetric synthesis of azasugars: synthesis, evaluation, and modeling of glycosidase inhibitors
…, RL Pederson, Z Zhong, Y Ichikawa…
Index: Kajimoto, Tetsuya; Liu, Kevin K.-C.; Pederson, Richard L.; Zhong, Ziyang; Ichikawa, Yoshitaka; Porco Jr., John A.; Wong, Chi-Huey Journal of the American Chemical Society, 1991 , vol. 113, # 16 p. 6187 - 6196
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Citation Number: 290
Abstract
Abstract: A combined fructose 1, 6diphosphate aldolase reaction and catalytic reductive amination has been used in the asymmetric synthesis of azasugars structurally corresponding to N-acetylglucosamine, N-acetylmannosamine, and deoxyhexoses. The 6- deoxyazasugars were prepared by direct hydrogenolysis of the aldolase product without removal of the 6-phosphate group. Both (R)-and (S)-3-azido-2-acetamidopropanal used ...
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