A simple synthesis of 2-substituted oxazolines and oxazines

A Cwik, Z Hell, A Hegedüs, Z Finta, Z Horváth

Index: Cwik, Agnieszka; Hell, Zoltan; Hegedues, Adrienn; Finta, Zoltan; Horvath, Zoltan Tetrahedron Letters, 2002 , vol. 43, # 22 p. 3985 - 3987

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Citation Number: 99

Abstract

Numerous methods have been developed for the preparation of 2-substituted oxazolines from carboxylic acids using high temperatures of up to 200–220°C, 4 repeated use of SOCl 2 , 5 phosphines together with harmful halogenated hydrocarbons such as CCl 4 or hexachloroethane, 2 or under other drastic reaction conditions. Some other methods using carboxylic esters, 6., and nitriles 7 or aldehydes 8 as starting materials have also been described but most of them utilize ...