Tetrahedron letters

Trifluoromethylated heterocycles from β-trifluoroacetyl-lactams and-benzolactams

JP Bouillon, C Ates, Z Janousek, HG Viehe

Index: Bouillon; Ates; Janousek; Viehe Tetrahedron Letters, 1993 , vol. 34, # 32 p. 5075 - 5078

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Citation Number: 30

Abstract

Preparation of β-trifluoroacetylated lactams 1a (n=0), 1b (n=1) and 2a (n=1) : Lactam was treated first with 1.5 eq. of NaH in boiling THF followed by ethyl trifluoroacetate (1.5 eq.). For β-trifluoroacetylated lactams 1c (n=2) and 2b (n=2) : Lactam was treated with 1.3 eq. of lithium diisopropyl amide at −78°C followed by addition of ethyl trifluoroacetate (1.2 eq.) at −20°C. ... All compounds in scheme 3 are characterized by IR, 1 H-NMR, 19 F-NMR, 13 C-NMR and MS.