Improved method for the synthesis of 1-vinylindole.

…, A Vasil'tsov, A Ivanov, A Mikhaleva…

Index: Shmidt; Protsuk; Vasil'Tsov; Ivanov; Mikhaleva; Trofimov Chemistry of Heterocyclic Compounds, 2013 , vol. 49, # 3 p. 404 - 407 Khim. Geterotsikl. Soedin., 2013 , vol. 49, # 3 p. 436 - 439,4

Full Text: HTML

Citation Number: 2

Abstract

Abstract A highly efficient method has been developed for the synthesis of 1-vinylindole based on the vinylation of indole by acetylene at atmospheric pressure using the superbase KOH-DMSO catalytic system. The method allows the preparation of the 1-vinylindole in 94% yield with a purity of 99%(after a single distillation of the crude product).[ABSTRACT FROM AUTHOR]

Related Articles:

Palladium-catalyzed stereocontrolled vinylation of azoles and phenothiazine

[Lebedev, Artyom Y.; Izmer, Vyatcheslav V.; Kazyul'kin, Denis N.; Beletskaya, Irina P.; Voskoboynikov, Alexander Z. Organic Letters, 2002 , vol. 4, # 4 p. 623 - 626]

Iridium-Catalyzed, Intermolecular Hydroamination of Unactivated Alkenes with Indoles

[Sevov, Christo S.; Zhou, Jianrong; Hartwig, John F. Journal of the American Chemical Society, 2014 , vol. 136, # 8 p. 3200 - 3207]

Direct N-and C-vinylation with trimethoxyvinylsilane

[Arsenyan, Pavel; Petrenko, Alla; Paegle, Edgars; Belyakov, Sergey Mendeleev Communications, 2011 , vol. 21, # 6 p. 326 - 328]

Palladium-assisted N-alkylation of indoles: attempted application to polycyclization

[Hegedus, Louis S.; Winton, Peter M.; Varaprath Sudarsanan Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2215 - 2221]

More Articles...