Highly regioselective synthesis of 1, 7-diprotected 1, 4, 7, 10-tetraazacyclododecane derivatives

PL Anelli, M Murru, F Uggeri, M Virtuani

Index: Anelli; Murru; Uggeri; Virtuani Journal of the Chemical Society - Series Chemical Communications, 1991 , # 18 p. 1317 - 1318

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Citation Number: 16

Abstract

Highly Regioselective Synthesis of 1,7=Diprotected 1,4,7,10-Tetraazacyclododecane Derivatives ... Pier Lucio Anelli," Marcella Murru, Fulvio Uggeri and Mario Virtuani Research and Development Division, Bracco SpA, Via E. Folli 50, 20734 Milan, Italy ... Reaction of dimethylformamide diethyl acetal with monoal kylated 1,4,7,1O-tetraazacyclododecane derivatives 3, followed by hydrolysis of the tricyclic intermediates 4, selectively affords 1,7-disu bstituted tetraazamacrocycles 5.