The Journal of Organic Chemistry

An air-stable catalyst system for the conversion of esters to alcohols

SC Berk, SL Buchwald

Index: Berk, Scott C.; Buchwald, Stephen L. Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3751 - 3753

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Citation Number: 100

Abstract

Summary: The combination of 5 mol 5% of Ti (Oi-Pr) 4 with 2.5-3.0 equiv of (EtO) 3SiH cleanly hydrosilylates esters to silyl ethers at 40-55 OC, which can be converted to the corresponding primary alcohols via aqueous allraline hydrolysis in excellent overall yield. The reaction can be carried out in the air, without solvent, and displays a high level of functional group compatibility.

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