Synthesis and biological characterization of new aminophosphonates for mitochondrial pH determination by 31P NMR spectroscopy

…, V Pique, L Michelet, A Krieger-Liszkay…

Index: Culcasi, Marcel; Casano, Gilles; Lucchesi, Celine; Mercier, Anne; Clement, Jean-Louis; Pique, Valerie; Michelet, Laure; Krieger-Liszkay, Anja; Robin, Maxime; Pietri, Sylvia Journal of Medicinal Chemistry, 2013 , vol. 56, # 6 p. 2487 - 2499

Full Text: HTML

Citation Number: 8

Abstract

A series of mitochondria targeted α-aminophosphonates combining a diethoxyphosphoryl group and an alkyl chain-connected triphenylphosphonium bromide tail were designed and synthesized, and their pH-sensitive 31P NMR properties and biological activities in vitro and in vivo were evaluated. The results showed a number of these mito-aminophosphonates exhibiting p K a values fitting the mitochondrial pH range, short relaxation, and chemical ...