Tetrahedron letters

Synthetic approaches to the southern part of cyclotheonamide C

DJ Aitken, S Faure, S Roche

Index: Aitken, David J.; Faure, Sophie; Roche, Stephane Tetrahedron Letters, 2003 , vol. 44, # 49 p. 8827 - 8830

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Citation Number: 17

Abstract

A synthetic equivalent of the southern segment of cyclotheonamide C, a cyclopentapeptide isolated from the sponge Theonella, has been synthesized via complementary Wadsworth– Emmons or palladium-catalysed methodologies followed by tandem oxidation/vinylogation in 41% overall yield (five steps) from readily available starting materials.