Palladium??Catalyzed Arylation of Methylene??Bridged Polyarenes: Synthesis and Structures of 9??Arylfluorene Derivatives

…, CC Hsiao, S Higashibayashi, H Sakurai…

Index: Chen, Jheng-Jhih; Onogi, Satoru; Hsieh, Ya-Chu; Hsiao, Chien-Chi; Higashibayashi, Shuhei; Sakurai, Hidehiro; Wu, Yao-Ting Advanced Synthesis and Catalysis, 2012 , vol. 354, # 8 p. 1551 - 1558

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Citation Number: 16

Abstract

Abstract In the presence of a catalytic system comprised of palladium (II) acetate and tricyclohexylphosphine, the reaction of fluorene with haloarenes generated 9-arylfluorenes in good to excellent yields. The scope and limitations of the coupling reaction were investigated. This synthetic protocol is more efficient than conventional methods. A wide range of functional groups, including alkyl, alkoxy, ester, and nitrile, can tolerate the ...