Synthesis of novel mast cell-stabilising and anti-allergic 1, 2, 3, 4-tetrahydro-1-naphthalenols and related compounds

JW Barlow, AP McHugh, O Woods, JJ Walsh

Index: Barlow, James W.; McHugh, Aengus P.; Woods, Orla; Walsh, John J. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 5 p. 1545 - 1554

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Citation Number: 9

Abstract

In a continuation of our studies into indan and tetralin systems as novel modulators of allergic and inflammatory phenomena, we have extended our work to include dimers linked via C–C bonds. Of these compounds, 2-Benzyl-2-[2-phenyl-1-ethenyl]-1, 2, 3, 4-tetrahydro-1- naphthalenol 12 exhibited most promising activity both in vitro and in vivo.