The Journal of Organic Chemistry

Synthesis of 2, 3-Dihydrobenzofurans by Mn (OAc) 3-Based Oxidative Cycloaddition of 2-Cyclohexenones with Alkenes. Synthesis of (±)-Conocarpan

BB Snider, L Han, C Xie

Index: Snider, Barry B.; Han, Luning; Xie, Chaoyu Journal of Organic Chemistry, 1997 , vol. 62, # 20 p. 6978 - 6984

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Citation Number: 82

Abstract

Oxidative cycloaddition of a 2-cyclohexenone or α-tetralone and an alkene with dried Mn (OAc) 3 in benzene at 80-140° C provides a general route to dihydrobenzofurans 15 and dihydronaphthofurans 17. Although the yields are modest, this one-pot reaction provides simple access to these compounds, which have previously been prepared by multistep routes. Oxidative cycloaddition of 2-cyclohexenones with β-methylstyrenes provides a ...