Novel 2-chloro-8-arylthiomethyldipyridodiazepinone derivatives with activity against HIV-1 reverse transcriptase
N Khunnawutmanotham, N Chimnoi, P Saparpakorn…
Index: Khunnawutmanotham, Nisachon; Chimnoi, Nitirat; Saparpakorn, Patchareenart; Pungpo, Pornpan; Louisirirotchanakul, Suda; Hannongbua, Supa; Techasakul, Supanna Molecules, 2007 , vol. 12, # 2 p. 218 - 230
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Citation Number: 6
Abstract
Abstract: Based on the molecular modeling analysis against Y181C HIV-1 RT, dipyridodiazepinone derivatives containing an unsubstituted lactam nitrogen and 2-chloro-8- arylthiomethyl were synthesized via an efficient route. Some of them were evaluated for their antiviral activity against HIV-1 RT subtype E and were found to exhibit virustatic activity comparable to some clinically used therapeutic agents.
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[Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241]