Convenient and simplified approaches to N-monoprotected triaminopropane derivatives: Key intermediates for bifunctional chelating agent synthesis

E Benoist, A Loussouarn, P Remaud, JF Chatal…

Index: Benoist, Eric; Loussouarn, Anthony; Remaud, Patricia; Chatal, Jean-Francois; Gestin, Jean-Francois Synthesis, 1998 , # 8 p. 1113 - 1118

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Citation Number: 23

Abstract

Abstract: High yields of selectively N-protected-1, 2, 3-triaminopropanes (1, 3 or 1, 2 functionalized diamines) were obtained in 6 or 4 steps from diamino alcohols or aminodiols, respectively. These two multi-step procedures involve protection of the amino group, substitution of the hydroxy group by an azido group and selective reduction. The conditions for the first procedure allow the preparation of various N2-monoprotected-1, 2, 3- ...

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