Organic letters

Organocatalytic Knoevenagel Condensations by Means of Carbamic Acid Ammonium Salts

N Mase, T Horibe

Index: Mase, Nobuyuki; Horibe, Takuya Organic Letters, 2013 , vol. 15, # 8 p. 1854 - 1857

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Citation Number: 25

Abstract

The Knoevenagel condensation between an active methylene compound and an aromatic aldehyde with a carbamic acid ammonium salt used as an organocatalyst gave the desired Knoevenagel products in up to 98% yield. The reaction occurred at rt and in a short reaction time under solvent-free conditions. In addition, no extraction, wash, or chromatography steps were needed to obtain a high-purity Knoevenagel product.