New antiinflammatory agents. 2. 5-Phenyl-3H-imidazo [4, 5-c][1, 8] naphthyridin-4 (5H)-ones: a new class of nonsteroidal antiinflammatory agents with potent activity …

…, T Tamura, S Sato, K Ohmori, S Ichikawa

Index: Suzuki, Fumio; Kuroda, Takeshi; Tamura, Tadafumi; Sato, Soichiro; Ohmori, Kenji; Ichikawa, Shunji Journal of Medicinal Chemistry, 1992 , vol. 35, # 15 p. 2863 - 2870

Full Text: HTML

Citation Number: 42

Abstract

1. Further modification of the compounds bearing l-phenyl-l, 8-naphthyridin-P-one as a mother skeleton led to 5-phenylimidazo [4, 5-c][lI8] naphthyridin-4 (5H)-one derivatives 2 and 3. Regioselective synthesis of these compounds bearing a substituent at the 1-or 3- position was conducted according to the method shown in Schemes I and 11. In this series of compounds, antiinflammatory activities were greatly influenced by the position and ...