Tetrahedron letters

Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls

M Yamashita, SH Lee, G Koch, J Zimmermann…

Index: Yamashita, Makoto; Lee, Sang-Hyeup; Koch, Guido; Zimmermann, Juerg; Clapham, Bruce; Janda, Kim D. Tetrahedron Letters, 2005 , vol. 46, # 33 p. 5495 - 5498

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Citation Number: 32

Abstract

The preparation of Wang resin bound α-diazo-β-ketoesters is described. These highly useful intermediates were used for the synthesis of a series of heterocycle libraries, which were obtained from the resin using TFA cleavage. In addition, a novel route for the synthesis of oxazolones using an N–H insertion strategy is disclosed.