New small molecule inhibitors of hepatitis C virus

…, C Cai, S Kota, V Takahashi, F Ni, AD Strosberg…

Index: Wei, Wanguo; Cai, Cuifang; Kota, Smitha; Takahashi, Virginia; Ni, Feng; Strosberg, A. Donny; Snyder, John K. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6926 - 6930

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Citation Number: 22

Abstract

New small molecule inhibitors of HCV were discovered by screening a small library of indoline alkaloid-type compounds. An automated assay format was employed which allowed identification of dimerization inhibitors of core, the capsid protein of the virus. These compounds were subsequently shown to block production of infectious virus in hepatoma cells.

Synthesis and evaluation of analogues of N-phthaloyl-l-tryptophan (RG108) as inhibitors of DNA methyltransferase 1

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Synthetic N-pyridinyl (methyl)-indol-3-ylpropanamides as new potential immunosuppressive agents

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New N-pyridinyl (methyl)-indolalkanamides acting as topical inflammation inhibitors

[Dassonville, Alexandra; Breteche, Anne; Evano, Johan; Duflos, Muriel; Le Baut, Guillaume; Grimaud, Nicole; Petit, Jean-Yves Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5441 - 5444]

New N-pyridinyl (methyl)-indolalkanamides acting as topical inflammation inhibitors

New small molecule inhibitors of hepatitis C virus

Abstract

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