Canadian Journal of Chemistry

The structure of monobrominated ethyl indole-3-carboxylate and the preparation of 7-bromoindole

BE Leggetter, RK Brown

Index: Leggetter,B.E.; Brown,R.K. Canadian Journal of Chemistry, 1960 , vol. 38, p. 1467 - 1471

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Citation Number: 15

Abstract

The compound reported by Majima and Kotake as ethyl 6-bromoindole-3-carboxylate, obtained from the monobromination of ethyl indole-3-carboxylate, when saponified, decarboxylated, and the product repeatedly crystallized from alcohol, actually gave a nearly equimolar mixture of 5-and 6-bromoindoles of constant melting point, 74-75°. 7-Bromoindole has been synthesized by two unambiguous routes.