A novel class of" GABAergic" agents: 1-aryl-3-(aminoalkylidene) oxindoles

…, HR Howard, BK Koe, A Weissman

Index: Sarges, Reinhard; Howard, Harry R.; Koe, B. Kenneth; Weissman, Albert Journal of Medicinal Chemistry, 1989 , vol. 32, # 2 p. 437 - 444

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Citation Number: 63

Abstract

Antagonism of mercaptopropionic acid (MPA) induced convulsions, reflecting a GABAergic mechanism, was observed in a series of l-aryl-3-(aminoalkylidene) oxindoles. Optimal MPA antagonism was associated with 3-ha10, 3-alkyl, and/or 4-alkoxy substituents in the pendant aryl ring and with (dimethylamino) methylene, 1-(dimethylamino)-ethylidene and N-methyl-2- pyrrolidinylidene side chains. The precise mechanism of action of these agents is unclear ...