In vitro and in vivo biological effects of novel arylimidamide derivatives against Trypanosoma cruzi

…, CF Da Silva, RR Tidwell, DA Patrick…

Index: Timm, Bruno Lisboa; Da Silva, Patricia Bernadino; Batista, Marcos Meuser; Da Silva, Francisca Hildemagna Guedes; Da Silva, Cristiane Franca; Tidwell, Richard R.; Patrick, Donald A.; Jones, Susan Kilgore; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Soeiro, Maria De Nazare C. Antimicrobial Agents and Chemotherapy, 2014 , vol. 58, # 7 p. 3720 - 3726

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Citation Number: 4

Abstract

ABSTRACT Chagas disease (CD), a neglected tropical disease caused by Trypanosoma cruzi, remains a serious public health problem in several Latin American countries. The available chemotherapies for CD have limited efficacy and exhibit undesirable side effects. Aromatic diamidines and arylimidamides (AIAs) have shown broad-spectrum activity against intracellular parasites, including T. cruzi. Therefore, our aim was to evaluate the biological ...