Synthesis, antiproliferative activity and DNA binding study of mixed ammine/cyclohexylamine platinum (II) complexes with 1-(substituted benzyl) azetidine-3, 3- …
Y Sun, S Gou, R Yin, P Jiang
Index: Sun, Yanyan; Gou, Shaohua; Yin, Runting; Jiang, Pingyuan European Journal of Medicinal Chemistry, 2011 , vol. 46, # 10 p. 5146 - 5153
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Citation Number: 23
Abstract
A novel series of ammine/cyclohexylamine platinum (II) complexes with 1-(substituted benzyl) azetidine-3, 3-dicarboxylates as leaving groups have been synthesized and characterized. All complexes were characterized by elemental analysis, IR, 1H NMR, and ESI-MS spectra. The in vitro antiproliferative activities of the platinum-based compounds have been investigated against several human cancer cell lines, indicating that ...
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