Synthesis

The First Direct Chlorination of Iodoarenes-A Side-chain Directed Process

D Mirk, O Kataeva, R Froehlich, SR Waldvogel

Index: Mirk, Daniela; Kataeva, Olga; Froehlich, Roland; Waldvogel, Siegfried R. Synthesis, 2003 , # 15 p. 2410 - 2414

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Citation Number: 3

Abstract

The synthesis of the diiodobenzenes started with the known multiple iodination of guaiacol 1, [10] providing in moderate yield the instable intermediate 2, which did not allow further purification. The subsequent conversion with methyl bromoacetate gave 3 in 35% yield over all steps. Deprotection of the common intermediate, followed by an alkylation of both phenolic groups, provided 4 in a total yield of 27% (Scheme [1] ). The easily synthesized substrates ...