Ethacrynic acid as a lead structure for the development of potent urease inhibitors

I Janser, CM Vortolomei, RK Meka, CA Walsh…

Index: Janser, Ingo; Vortolomei, Caitlyn M.; Meka, Ranjith K.; Walsh, Courtney A.; Janser, Romy F.J. Comptes Rendus Chimie, 2013 , vol. 16, # 7 p. 660 - 664

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Citation Number: 2

Abstract

Abstract Ethacrynic acid and a series of its analogues were synthesized and subsequently evaluated for their inhibitory effect on jack bean urease. Ethacrynic acid showed, even at low concentrations, very potent inhibitory activity against the enzyme. For ethacrynic acid, the inhibition potential increased with increasing preincubation time of ethacrynic acid and enzyme, whereas for some other compounds a higher preincubation time lead to a ...