… Syntheses of 5H-Pyrido (4, 3-b) indole (. GAMMA.-Carboline) Derivatives Having a Methoxycarbonyl Group at the 4-Position Based on 1-Hydroxyindole Chemistry.

M SOMEI, F YAMADA, G YAMAMURA

Index: Somei, Masanori; Yamada, Fumio; Yamamura, Gaku Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 2 p. 191 - 198

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Abstract

A simple synthetic method for 5H-pyrido [4, 3-b] indole (γ-carboline) derivatives having a methoxycarbonyl group at the 4-position was developed based on 1-hydroxyindole chemistry. By applying the method, various 3-substituted metyl 5H-pyrido [4, 3-b] indole-4- carboxylates and 2-substituted methyl 2, 3-dihydro-3-oxo-5H-pyrido [4, 3-b] indole-4- carboxylates were prepared.

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