Design and Synthesis of 4??(2, 4, 5??Trifluorophenyl) butane??1, 3??diamines as Dipeptidyl Peptidase IV Inhibitors

L Zhu, Y Li, L Qiu, M Su, X Wang, C Xia, Y Qu…

Index: Zhu, Linrong; Li, Yuanyuan; Qiu, Ling; Su, Mingbo; Wang, Xin; Xia, Chunmei; Qu, Yi; Li, Jingya; Li, Jia; Xiong, Bing; Shen, Jingkang ChemMedChem, 2013 , vol. 8, # 7 p. 1104 - 1116

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Citation Number: 7

Abstract

Abstract The worldwide prevalence of diabetes has spurred numerous studies on the development of new antidiabetic medicines. As a result, dipeptidyl peptidase IV (DPP4) has been recognized as a validated target. In our efforts to discover new DPP4 inhibitors, we analyzed the complexed structures of DPP4 available in Protein Data Bank and designed a series of triazole compounds. After enzyme activity assays and crystallographic ...