Journal of medicinal chemistry

Aliphatic propargylamines: potent, selective, irreversible monoamine oxidase B inhibitors

PH Yu, BA Davis, AA Boulton

Index: Yu, Peter H.; Davis, Bruce A.; Boulton, Alan A. Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3705 - 3713

Full Text: HTML

Citation Number: 132

Abstract

A series of aliphatic propargylamine derivatives has been synthesized. Some of them possess highly potent, irreversible, selective, inhibitory activity toward monoamine oxidase B (MAO-B). The potency of the inhibitors is related to chain length and substitution of a hydrogen on the terminal carbon of the aliphatic chain. MA0 inhibitory activity as assessed in vitro increased as the aliphatic carbon chain length increased. Substitution of a hydrogen ...