Archives of pharmacal research

Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents

AT Taher, NA Khalil, EM Ahmed

Index: Taher, Azza T.; Khalil, Nadia A.; Ahmed, Eman M. Archives of Pharmacal Research, 2011 , vol. 34, # 10 p. 1615 - 1621

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Citation Number: 25

Abstract

Abstract A series of new isatin-thiazoline 3a–h and isatin-benzimidazole 4a–h derivatives were synthesized via condensation of isatin Mannich bases 2a–h with either 2- aminothiazoline or 2-aminobenzimidazole. The structures of the newly synthesized compounds were characterized by spectral data. The anti-breast cancer activity of some of the synthesized compounds was assessed in the MCF-7 human breast cancer cell line. ...