Tetrahedron letters

Novel gallium-mediated C3-allylation of indoles and pyrroles in aqueous media promoted by Bu 4 NBr

D Prajapati, M Gohain, BJ Gogoi

Index: Prajapati, Dipak; Gohain, Mukut; Gogoi, Baikuntha J. Tetrahedron Letters, 2006 , vol. 47, # 21 p. 3535 - 3539

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Citation Number: 24

Abstract

A mild and efficient protocol for the coupling of indoles and pyrroles with allyl halides such as allyl bromide, crotyl bromide and propargyl bromide in the presence of gallium metal in a Bu4NBr–DMF–H2O system has been developed. The reaction is equally effective when cadmium is used in lieu of gallium and the corresponding 3-allyl indoles and 3-allyl pyrroles were obtained in almost comparable yields.

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