1-Acyltriazoles as antiinflammatory agents

…, LM Simpkins, DM Palmer, RC Millonig

Index: Wade; Vogt; Kissick; Simpkins; Palmer; Millonig Journal of Medicinal Chemistry, 1982 , vol. 25, # 3 p. 331 - 333

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Citation Number: 52

Abstract

Discussion The biological data for 3c are summarized in Table I1 along with the corresponding results obtained with a standard arylacetic acid antiinflammatory agent, ibuprofen. Comparison of these results indicates that 3c possesses oral activity in the primary test system, Le., mouse active Arthus (MAA), with an ID,= 342 mg/kg and is approximately 10 times more potent when administered via the intraperitoneal route, ie, ID ...