Meldrum's acid in organic synthesis. 2. A general and versatile synthesis of. beta.-keto esters

Y Oikawa, K Sugano, O Yonemitsu

Index: Oikawa,Y. et al. Journal of Organic Chemistry, 1978 , vol. 43, # 10 p. 2087 - 2088

Full Text: HTML

Citation Number: 339

Abstract

Summary: On acylation with various acyl chlorides Meldrum's acid, 2.2-dimethyl-1, 3- dioxane-4, 6-dione, gave the corresponding acyl Meldrum's acids, which readily underwent alcholysis with methanol, ethanol, tert-butyl alcohol, benzyl alcohol, and trichloroethanol to give various (3-keto esters; the acyl Meldrum's acids can be regarded as a synthetic equivalent of mixed diketenes.