Highly Enantioselective Hydrogenation of β, β??Disubstituted Nitroalkenes

S Li, K Huang, B Cao, J Zhang, W Wu…

Index: Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8573 - 8576

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Citation Number: 21

Abstract

Enantiomerically pure nitroalkanes are valuable intermediates in organic synthesis. They can be easily converted to other versatile building blocks, such as amines, aldehydes, carboxylic acids, nitrile oxides, and denitrated compounds.[1] Structural motifs derived from chiral β-branched nitroalkanes can be found in many small molecule pharmaceuticals, such as catramilast, for the treatment of atopic dermatitis, the muscle relaxant baclofen,[2] and ...